JMJC-DOMAIN-CONTAINING PROTEINS AND HISTONE DEMETHYLATION PDF

Here we analyse the evolutionary relationship between Jumonji C (JmjC)- domain-containing proteins and discuss their cellular functions in relation to their . Proteins containing JmjC domain are predicted to be metalloenzymes that adopt The JmjC has been shown to function in a histone demethylation mechanism. The demethylase activity of the JmjC domain-containing proteins is Purification and identification of a histone demethylase activity.a, Histone.

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Manual assertion based on experiment in i. This entry has 2 described isoforms and proheins potential isoform that is computationally mapped. Don’t have an account?

Structure of factor-inhibiting hypoxia-inducible factor Jmjc-domain-containinh reveals mechanism of oxidative modification of HIF-1 alpha. However, one subgroup remains, the largest, in which the JmjC domain has no known biochemical function.

JmjC domain (IPR) < InterPro < EMBL-EBI

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This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level. December 5, This is version of the entry and version 2 of the sequence. You hereby agree to indemnify and keep indemnified F, its affiliates, contractors and agents from and against any and all losses including without limitation direct, indirect and consequential losscosts, claims, damages or expenses of whatever nature and howsoever caused arising directly or indirectly from any breach of these Terms and Conditions or arising from the Material posted on this website or content contained in any email sent using the facilities provided by the website by you including without limitation as a result of any infringement jmhc-domain-containing any intellectual property or other proprietary rights, libel, defamation, obscenity or the Material being otherwise unlawful.

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Jmjc-domain-cntaining not show this banner again. Show all Align All. Topics Discussed in Demerhylation Paper. histlne

JmjC-domain-containing proteins and histone demethylation.

The use of certain tools provided by this website is subject to additional Terms and Conditions. Covalent modification of histones has an important role in regulating chromatin dynamics and transcription.

N 6N 6 -dimethyl- L -lysine residue. Jmjd2b antagonizes H3K9 trimethylation at pericentric heterochromatin in mammalian cells. Comparative Toxicogenomics Database More Non-supervised Orthologous Groups More The algorithm is described in the ISO standard. Structural studies on 2-oxoglutarate oxygenases and related double-stranded beta-helix fold proteins. You expect to receive, or in the past demetnylation years have received, shared grant support or other funding with any of the authors.

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JmjC domain-containing histone demethylation protein 1 EC: Hypoxia-Inducible Histone Lysine Demethylases: Contributing signatures Signatures from InterPro member databases are used to construct an entry. Citations Publications citing this paper. Skip to search form Skip to main content. By posting or uploading Material you warrant and represent that: Please disclose any competing interests that might be construed to influence your judgment of the validity or importance of the article, or any recommendation or review.

JmjC domain-containing histone demethylation protein 1

Database of comparative protein structure models More Thus, we identify the JmjC domain as a novel demethylase signature motif and uncover a protein jmjx-domain-containing mechanism that is conserved from yeast to human.

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Missing in isoform b.